7-Chlorothieno[3,2-b]pyridine → tert-Butyl 2-(4-(7-chlorothieno[3,2-b]pyridin-2-yl)-1H-pyrazol-1-yl)ethyl(methyl)carbamate

Participants

Role	Name	HCID	Charge
Reactant	7-Chlorothieno[3,2-b]pyridine	HCID 11275251	—
Reactant	7-Chloro-2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridine	HCID 59424524	—
Reactant	tert-butyl 2-(4-iodo-1H-pyrazol-1-yl)ethyl(methyl)carbamate	HCID 59424644	—
Product	tert-Butyl 2-(4-(7-chlorothieno[3,2-b]pyridin-2-yl)-1H-pyrazol-1-yl)ethyl(methyl)carbamate	HCID 59457667	75%

Reaction Steps

Starting from the chloride 2 and following the procedure described above for the synthesis of 175 (scheme 35, example 138), but replacing 4-iodo-1-methyl-1H-imidazole with tert-butyl 2-(4-iodo-1H-pyrazol-1-yl)ethyl(methyl)carbamate, title compound 180 was obtained in 75% yield. LRMS (M+1) 393.1 (100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790729B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-810691f3c8a3421fa866e51096799832
Source note	uspto-grants-2010_09