1-Phenylcyclopropanecarbonyl isothiocyanate → N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl) 1-phenylcyclopropanecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Phenylcyclopropanecarbonyl isothiocyanate	HCID 21890610	—
Reactant	N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide	HCID 24901699	—
Reactant	1-(4-(7-Benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea	HCID 86609660	—
Product	N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl) 1-phenylcyclopropanecarboxamide	HCID 86604183	41%

Reaction Steps

Starting from the amine 169 (scheme 33), following the procedures described above for the synthesis of compound 170a (example 133) but replacing 2-phenylacetyl isothiocyanate with 1-phenylcyclopropanecarbonyl isothiocyanate, title compound 192d was obtained in 41% yield. Characterization of 192d is provided in table 18.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790729B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-6c18a5d479cc45f1ab4d5e252cc30ce1
Source note	uspto-grants-2010_09