7-(2-Fluoro-4-nitrophenoxy)-1-methyl-1H-pyrrolo[2,3-c]pyridine → Fluoro-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-7-yloxy)benzenamine

HRID 1711038Notes

Reaction equation

HRID 1711038 reaction equation
F[C:2]1[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[N:6]=[CH:7][CH:8]=[C:9]2[CH:13]=[CH:12][N:11]([CH3:14])[C:10]=12.N1C2=C(OC3C=CC(N)=CC=3[F:39])N=CC=C2C=C1>>[F:39][C:16]1[CH:15]=[C:3]([O:4][C:5]2[N:6]=[CH:7][CH:8]=[C:9]3[CH:13]=[CH:12][N:11]([CH3:14])[C:10]=23)[CH:2]=[CH:18][C:17]=1[NH2:19]

Participants

3

Reactant 2

HCID 594246057-(2-Fluoro-4-nitrophenoxy)-1-methyl-1H-pyrrolo[2,3-c]pyridineHCID 594246294-(1H-Pyrrolo[2,3-c]pyridin-7-yloxy)-3-fluorobenzenamine

Product 1

HCID 86644588Fluoro-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-7-yloxy)benzenamineYield 89%

Procedure

Starting from the compound 264 and following the procedure described above for the synthesis of amine 261 (scheme 59, step 3, example 218), title compound 265 was obtained in 89% yield as an off-white solid. MS (m/z): 258.1 (M+H) (found).

Sources & evidence

ORD record
ord-87d4b93d18ed4a3a8da0b27d89780fde
Source dataset
uspto-grants-2010_09
Patent number
US07790729B2

Reaction notes

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