Methyl iodide → N-(4-(1-Benzyl-1H-pyrrolo[2,3-c]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide

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Reaction Steps

Starting from the compound 259 and following the procedures described above for the synthesis of compound 262b (scheme 60, step 4, example 219) but using benzyl bromide in step 1 instead of methyl iodide, title compound 262c was obtained. 1H NMR (DMSO-d6) δ (ppm): 12.36 (s, 1H), 11.76 (s, 1H), 7.78 (m, 1H), 7.58(t, 1H, J1=J2=2.7 Hz), 7.50(d, 1H, J=5.7 Hz), 7.34 (m, 5H), 7.30-7.221 (m, 5H), 7.15(dd, 1H, J1=8.1 Hz, J2=0.4 Hz), 7.10(t, 1H), 6.60(d, 1H, J=2.9 Hz), 5.68 (s, 2H), 3.82 (s, 2H). MS (m/z): 511.2 (M+H) (found).

Provenance & Evidence