7-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridine → 6-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine

HRID 1711046Notes

Reaction equation

HRID 1711046 reaction equation
[Br:1][C:2]1[C:3](Cl)=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[F:12][C:13]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:14]=1[O:15]C1N=CC=C2C=CNC=12>>[Br:1][C:2]1[C:3]([O:15][C:14]2[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:13]=2[F:12])=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 594246417-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridineHCID 594246556-Bromo-7-chlorothieno(3,2-b)pyridine

Product 1

HCID 594244576-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridineYield 61%

Procedure

Starting from the compound 271 and following the procedure described above for the synthesis of compound 260 (scheme 59, example 218, step 2), title compound 272 was obtained in 61% yield as an off-white solid. MS (m/z): 368.9 (M+H).

Sources & evidence

ORD record
ord-ae19a326e025406fbb57d2235377f516
Source dataset
uspto-grants-2010_09
Patent number
US07790729B2

Reaction notes

Loading…