N-(4-(1H-Pyrrolo[2,3-c]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide → N-(4-(6-Bromothieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide

Participants

Role	Name	HCID	Charge
Reactant	N-(4-(1H-Pyrrolo[2,3-c]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide	HCID 58621945	—
Reactant	4-(6-Bromothieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine	HCID 59424676	—
Product	N-(4-(6-Bromothieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide	HCID 59424509	99%

Reaction Steps

Starting from the compound 273 and following the procedure described above for the synthesis of compound 262a (scheme 59, example 218, step 4), title compound 274 was obtained in 99% yield as a white solid. 1H NMR (DMSO-d6) δ (ppm): 12.44 (s, 1H), 11.79(s, 1H), 8.82 (s, 1H), 8.03(d, 1H), 7.99(dd, 1H), 7.54(d, 1H), 7.41(dd, 1H), 7.32-7.24 (m, 6H), 3.80 (s, 2H). MS (m/z): 517.0 (M+H) (found).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790729B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-b0bb5146cc0246f7aaab454d27104133
Source note	uspto-grants-2010_09