4-(2-(1-Ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine → HCID 68697453, compound

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Reaction Steps

A mixture of 308 (320 mg, 0.90 mmol) and (2-fluoro-phenyl)-acetyl isocyanate (600 mg, 3.35 mmoL) [A. J. Hill et al. JACS, 62; 1940; 1595] was stirred for 1 h at room temperature, loaded directly onto a flash chromatography column and gradient eluted with EtOAc, to MeOH/EtOAc (20:80), to afford the title compound 309b in 42% yield as a white solid. 1H NMR (d-DMSO) δ (ppm): 11.10 (s, 1H), 10.58 (s, 1H), 8.42(d, 1H, J=5.5 Hz), 7.94(d, 1H, J=1.1 Hz), 7.82-7.77 (m, 2H), 7.65 (s, 1H), 7.45-7.30 (m, 4H), 7.19-7.16 (m, 2H), 6.54(dd, 1H, J1=0.7 Hz, J2=5.4 Hz), 4.04(q, 2H), 3.83 (s, 2H), 1.38(t, 3H). MS (m/z): 534.1 (M+H) (found).

Provenance & Evidence