Water → HCID 59457683, compound

Participants

Reaction Steps

A suspension of methyl 2-(2-(1-fluorovinyl)phenyl)acetate (334, 770.8 mg, 4.015 mmol) (Hakamoto T.; Kobavashi T. J. Org. Chem. 2003, 68, 6354-6359) and LiOH×H2O (185 mg, 4.41 mmol) in H2O/THF (1:1, 11 mL) was stirred overnight at room temperature. The THF was evaporated off under reduced pressure; the aqueous residue was diluted with water, washed with EtOAc, acidified to pH˜3 by addition of 1N HCl and extracted with DCM. The organic extract was dried over anhydrous Na2SO4 and concentrated under reduced pressure affording 335 (557.2 mg, 77% yield) as a white solid. LCMS: (M−1) 187.1 (100%).

Provenance & Evidence