Iodoethane → HCID 59457732, compound

Participants

Reaction Steps

To a solution of NaN3 (107.3 mg, 1.65 mmol) in DMSO (5 ml) was added ethyl iodide (257 mg, 1.65 mmol) and the reaction mixture was stirred for 12 hrs at RT. The alkyne 410 (520 mg, 1.65 mmol) and Cu(OAc)2×H2O (66 mg, 0.2 eq, 0.331 mmol) were added and the deep red reaction mixture was allowed to stir at RT overnight. After 72 hrs, an orange precipitate had formed. The mixture was diluted with water and the solid was collected by filtration. The orange solid 413 was used directly in the next step with no additional purification (620 mg, 97% yield). LCMS: 386.2 (M+H).

Provenance & Evidence