反应详情

A solution of 448 (408 mg, 0.99 mmol) and NH4Cl (45 mg, 084 mmol) in 2:1 mixture of EtOH/water (15 mL) was treated with iron powder (472 mg, 8.43 mmol) and heated to reflux under vigorous stirring for 1 hour. The reaction mixture was then filtered through celite and concentrated yielding 449 which was used without further purification (278 mg, 74% yield). LCMS: (M+H) 382.0.

1. temperatureheated
2. temperatureto reflux
3. filtrationThe reaction mixture was then filtered through celite
4. concentrationconcentrated