1,4-Dioxa-8-azaspiro(4.5)decane → HCID 68774873, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1,4-dioxa-8-azaspiro[4.5]decane (8.00 g, 55.9 mmol) in MeOH (70 ml) was added crotononitrile (18.74 g, 279 mol). The mixture was heated at 50° C. for 16 hours. MeOH and excess crotononitrile were removed by evaporation under reduced pressure to give 3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyronitrile (11.75 g, 100%) as a pale yellow oil.

Provenance & Evidence