HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethylbenzoic acid → N-[3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyl]-2,6-dimethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethylbenzoic acid | HCID 12439 | — |
| Reactant | 3-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine | HCID 68775101 | — |
| Product | N-[3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyl]-2,6-dimethyl-benzamide | HCID 68774634 | 83.9% |
Reaction Steps
Using general procedure E with 3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine (2.30 g, 10.7 mmol) and 2,6-dimethylbenzoic acid (1.77 g, 11.8 mmol) followed by purification by column chromatography on silica gel (1-5% MeOH/CH2Cl2) gave N-[3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyl]-2,6-dimethyl-benzamide (3.11 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790747B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-e94b30d32988447ea46b9c5e75471b0f |
| Source note | uspto-grants-2010_09 |