Potassium Carbonate → HCID 87571300, compound

Participants

Reaction Steps

Using general procedure C the substrate (5.0 g, 0.012 mol) gave the desired amine. Due to the high water solubility of the compound, the mixture was neutralized with solid K2CO3 and the product was purified by column chromatography to afford (R,S)-3-[1-(3-amino-1-methyl-propyl)-piperidine-4-yl]-4-phenyl-oxazolidine-2-thione (1.6 g, 42%). 1H NMR (CDCl3) δ 0.90 (d, 3H), 0.90-1.0 (m, 1H), 1.31-1.91 (m, 8H), 2.03-2.05 (m, 1H), 2.61-2.75 (m, 6H), 4.32-4.36 (m, 2H), 4.94-4.98 (m, 1H), 5.29 (d, 1H), 7.25-7.42 (m, 5H).

Provenance & Evidence