HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl 2-pyridin-2-ylsulfanylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | HCID 178418616 | HCID 178418616 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 2-pyridin-2-ylsulfanylacetate | HCID 15388132 | 94.3% |
Reaction Steps
A solution of 2-mercaptopyridine (484 mg, 4.35 mmol), methyl bromoacetate (0.45 ml, 4.8 mmol), and Et3N (0.79 ml, 5.7 mmol) in CH3CN (22 ml) was stirred at room temperature for 20 h to give (pyridin-2-ylsulfanyl)-acetic acid methyl ester as a colorless oil (752 mg, 94%) after aqueous work-up and purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790747B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-ed7db3d08ce44ab9ad6483509774bedd |
| Source note | uspto-grants-2010_09 |