反应详情

温度

50 °C

N-Acetylglycine (0.031 ml, 0.22 mmol) was dissolved in 1:1 10N NaOH/THF (2 ml) and was stirred at 50° C. for 1 h. The mixture was neutralized to pH 4 with 6N HCl, then concentrated. The yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml), filtered to remove inorganic salts, and concentrated. The solid obtained was diluted again with 1:1 MeOH/CH2Cl2 and concentrated to give (2-oxo-pyrrolidin-1-yl)-acetic acid as a white solid. The crude product was used in the next reaction without purification.

1. concentrationconcentrated
2. additionThe yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml)
3. filtrationfiltered
4. customto remove inorganic salts
5. concentrationconcentrated
6. customThe solid obtained
7. concentrationconcentrated