Cyclohexaneacetic acid → HCID 68777476, compound

HRID 1711139Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:22]1([CH2:28][C:29](O)=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:29](=[O:30])[CH2:28][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 21363Cyclohexaneacetic acid

HCID 15380687tert-Butyl 4-(benzylamino)piperidine-1-carboxylate

Product 1

HCID 68777476HCID 68777476, compoundYield 85%

Procedure

Using general procedure E, 4-benzylamino-piperidine-1-carboxylic acid tert-butyl ester (300 mg, 1.03 mmol) and cyclohexylacetic acid (161 mg, 1.13 mmol) afforded 4-[benzyl-(2-cyclohexyl-acetyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a white solid (360 mg, 85%).

Sources & evidence

ORD record: ord-722207d785f54d6ea89bf857194f4381
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790747B2

Reaction notes

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