HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylbenzylamine → 4,6-Dimethyl-pyrimidine-5-carboxylic acid {3-[4-(3-methyl-benzylamino)-piperidin-1-yl]-butyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylbenzylamine | HCID 66015 | — |
| Reactant | 4,6-Dimethylpyrimidine-5-carboxylic acid [3-(4-oxo-piperidin-1-yl)-butyl]-amide | HCID 59458243 | — |
| Product | 4,6-Dimethyl-pyrimidine-5-carboxylic acid {3-[4-(3-methyl-benzylamino)-piperidin-1-yl]-butyl}-amide | HCID 86629516 | 72.1% |
Reaction Steps
Using general procedure A, 3-methylbenzylamine (30 μL, 0.23 mmol) and 4,6-dimethylpyrimidine-5-carboxylic acid [3-(4-oxo-piperidin-1-yl)-butyl]-amide (66 mg, 0.22 mmol) afforded 4,6-dimethyl-pyrimidine-5-carboxylic acid {3-[4-(3-methyl-benzylamino)-piperidin-1-yl]-butyl}-amide (65 mg, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790747B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-bd2e2ce5ef8c4cdbaa8218d1ce5d7783 |
| Source note | uspto-grants-2010_09 |