Methyl isothiocyanate → HCID 86629529, compound

Participants

Reaction Steps

Following general procedure H: to ((R)-3-{4-[(Thiophen-3-ylmethyl)-amino]-piperidin-1-yl}-butyl)-carbamic acid tert-butyl ester (1.0 g, 2.72 mmol) in dry CH2Cl2 (20 ml) was added methylisothiocyanate (223 μl, 3.26 mmol). The reaction mixture was then allowed to stir at room temperature overnight under N2 pressure to yield {(R)-3-[4-(3-methyl-1-thiophen-3-ylmethyl-thioureido)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl ester as yellow oil.

Provenance & Evidence