Potassium Carbonate → HCID 13487836, compound

Participants

Reaction Steps

To a solution of 1,1-diacetyl-2,3-dimethyl-isothiourea (0.17 g, 0.90 mmol) in MeOH (10 ml) was added K2CO3 (250 mg, 1.81 mmol) and the reaction stirred at room temperature for 1.5 h. The mixture was concentrated, diluted with CH2Cl2 (25 ml) and water (20 ml) and the aqueous layer was extracted with CH2Cl2 (2×10 ml), dried (Na2SO4) and concentrated to afford 1-acetyl-2,3-dimethyl-isothiourea (112 mg, 85%) as a white solid. 1H NMR (CDCl3) δ 2.10 (s, 3H), 2.43 (s, 3H), 2.93 (s, 3H).

Provenance & Evidence