Trifluoroacetic acid → HCID 68776969, compound

Participants

Reaction Conditions

Reaction Steps

The above carbamate (159 mg, 0.407 mmol) was dissolved in CH2Cl2 (4 ml) and then cooled to 0° C. Trifluoroacetic acid (2.0 ml, 26 mmol) was added dropwise to the cooled solution and then the reaction was allowed to stir for 10 minutes at 0° C., and then 30 minutes at room temperature. The solution was concentrated and the residue dissolved in 9:1 CH2Cl2/MeOH (10 ml). mgSO4 was added and the reaction mixture stirred for 30 minutes, then potassium carbonate (373 mg, 2.70 mmol) was added and the solution was concentrated to afford 2-[1-(3-amino-1-methylpropyl)piperidin-4-ylamino]-2-phenylethanol as a light yellow oil (106 mg, 89%) following purification.

Provenance & Evidence