Cyclohexylamine → HCID 68775173, compound

HRID 1711183Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[F:20])[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:21]1([NH2:27])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH:9]([C:10](=[O:12])[NH:27][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[F:20])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 7965Cyclohexylamine

HCID 58353255HCID 58353255, compound

Product 1

HCID 68775173HCID 68775173, compoundYield 90%

Procedure

Using general procedure E, tert-butoxycarbonylamino-(2,5-difluorophenyl)-acetic acid (1.84 g, 6.40 mmol) and cyclohexylamine (730 μL, 634 mg, 6.40 mmol) afforded [cyclohexylcarbamoyl-(2,5-difluorophenyl)-methyl]-carbamic acid tert-butyl ester (2.12 g, 90%).

Sources & evidence

ORD record: ord-706b526ebdf04988b57755c5411899a1
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790747B2

Reaction notes

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