[3-(4-Oxo-piperidin-1-yl)-butyl]-carbamic acid tert-butyl ester → {3-[4-(2-Cyclohexylamino-1-{2,5-difluorophenyl}-ethylamino)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl ester

HRID 1711184Notes

Reaction equation

HRID 1711184 reaction equation
[CH:1]1([NH:7][CH2:8][CH:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=2[F:18])[NH2:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:19]([O:23][C:24](=[O:37])[NH:25][CH2:26][CH2:27][CH:28]([N:30]1[CH2:35][CH2:34][C:33](=O)[CH2:32][CH2:31]1)[CH3:29])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24](=[O:37])[NH:25][CH2:26][CH2:27][CH:28]([N:30]1[CH2:35][CH2:34][CH:33]([NH:10][CH:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=2[F:18])[CH2:8][NH:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH2:32][CH2:31]1)[CH3:29])([CH3:20])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 68775260[3-(4-Oxo-piperidin-1-yl)-butyl]-carbamic acid tert-butyl esterHCID 86629532N2-cyclohexyl-1-(2,5-difluorophenyl)-ethane-1,2-diamine

Product 1

HCID 68776880{3-[4-(2-Cyclohexylamino-1-{2,5-difluorophenyl}-ethylamino)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl esterYield 89.3%

Procedure

Using general procedure A, N2-cyclohexyl-1-(2,5-difluorophenyl)-ethane-1,2-diamine (750 mg, 2.95 mmol) and [3-(4-oxo-piperidin-1-yl)-butyl]-carbamic acid tert-butyl ester (797 mg, 2.95 mmol) afforded {3-[4-(2-cyclohexylamino-1-{2,5-difluorophenyl}-ethylamino)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl ester (1.34 g, 89%).

Sources & evidence

ORD record
ord-6538173f0d4648b9a922fd15eb041ad7
Source dataset
uspto-grants-2010_09
Patent number
US07790747B2

Reaction notes

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