HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxane-4-carboxylic acid → ((R)-1-phenyl-2-[(tetrahydro-pyran-4-carbonyl)-amino]ethyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxane-4-carboxylic acid | HCID 219302 | — |
| Reactant | [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER | HCID 15675183 | — |
| Product | ((R)-1-phenyl-2-[(tetrahydro-pyran-4-carbonyl)-amino]ethyl)-carbamic acid tert-butyl ester | HCID 68777114 | 99.8% |
Reaction Steps
Using general procedure E, ((R)-2-amino-1-phenyl-ethyl)-carbamic acid tert-butyl ester (616 mg, 2.61 mmol) and tetrahydro-pyran-4-carboxylic acid (339 mg, 2.61 mmol) afforded ((R)-1-phenyl-2-[(tetrahydro-pyran-4-carbonyl)-amino]ethyl)-carbamic acid tert-butyl ester (908 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790747B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-cc551213da504b86a459a942394e1d34 |
| Source note | uspto-grants-2010_09 |