HCID 68775359, compound → HCID 68775158, compound

Participants

Reaction Steps

To a solution of (3-{4-[(R)-3-(2-nitro-phenyl)-2-oxo-5-phenyl-imidazolidin-1-yl]-piperidin-1-yl}-butyl)-carbamic acid tert-butyl ester (180 mg, 0.334 mmol) in CH3OH (3 ml) was added Pd/C (20 mg, 50%). The mixture was hydrogenated under H2 (2 atm.) for 10 min. Filtration and concentration gave (3-{4-[(R)-3-(2-amino-phenyl)-2-oxo-5-phenyl-imidazolidin-1-yl]-piperidin-1-yl}-butyl)-carbamic acid tert-butyl ester (160 mg, 94%). Treatment with TFA (1 ml) and CH2Cl2 (1 ml) according to general procedure C gave (R)-3-[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-1-(2-amino-phenyl)-4-phenyl-imidazolidin-2-one (114 mg, 94%).

Provenance & Evidence