HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → (3R,3aR,6S,6aR)-6-azido-hexahydro-furo[3,2-b]furan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | (3R,3aS,6R,6aR)-6-Hydroxyhexahydrofuro[3,2-b]furan-3-yl 4-methylbenzenesulfonate | HCID 13014014 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (3R,3aR,6S,6aR)-6-azido-hexahydro-furo[3,2-b]furan-3-ol | HCID 51345858 | — |
Reaction Steps
A solution of 2.5 g of toluene-4-sulfonic acid (3R,3aS,6R,6aR)-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester in 30 ml of DMF is heated with 0.8 g of sodium azide under reflux for 2 hours, solvent is distilled off and the distillation residue obtained is dissolved in EtAc and extracted with H2O. The organic phase obtained is dried and solvent is evaporated. (3R,3aR, 6S,6aR)-6-azido-hexahydro-furo[3,2-b]furan-3-ol is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790749B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-26fed8e8baa34b4bb6fb810dec483173 |
| Source note | uspto-grants-2010_09 |