反应详情

A solution of 4-oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carboxylic acid ethyl ester (iv) in DCM at 0° C. is treated with diisobutylaluminum hydride (“DIBAL-H”) and is allowed to warm to room temperature. The reaction is quenched with a saturated solution of sodium potassium tartrate and partitioned. The organic layer is dried over MgSO4, filtered and treated with manganese dioxide (“MnO2”). After stirring for 16 h at room temperature, the reaction is filtered and is concentrated to give 4-oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carbaldehyde (v).

1. customThe reaction is quenched with a saturated solution of sodium potassium tartrate
2. custompartitioned
3. dry with materialThe organic layer is dried over MgSO4
4. filtrationfiltered
5. additiontreated with manganese dioxide (“MnO2”)
6. filtrationthe reaction is filtered
7. concentrationis concentrated