HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Amino-N-(1,1-dimethylethyl)benzenesulfonamide | HCID 832627 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide | HCID 54850284 | 53.1% |
Reaction Steps
To a solution of 4-amino-N-tert-butyl-benzenesulfonamide (J. Med. Chem. (2003), 46(16), 3463-3475, 228 mg, 1.00 mmol) in DCM (10 mL), NBS (178 mg, 1.00 mmol) was added. The resulting mixture was stirred at RT for 30 min and washed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL). The organic layer was separated, dried and concentrated to obtain 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide (163 mg, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790724B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-82168f1fbbe246799a59bd1f0f3f1298 |
| Source note | uspto-grants-2010_09 |