N-bromobutanimide → 2-Bromo-4-(6-methoxy-pyridin-3-yl)-phenylamine

HRID 1711299Notes

Reaction equation

HRID 1711299 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C1C(=O)N([Br:23])C(=O)C1>>[Br:23][C:13]1[CH:14]=[C:9]([C:6]2[CH:7]=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:10]=[CH:11][C:12]=1[NH2:15]

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 114355844-(6-Methoxypyridin-3-yl)aniline

Product 1

HCID 587548092-Bromo-4-(6-methoxy-pyridin-3-yl)-phenylamine

Procedure

The title compound was prepared from 4-(6-methoxy-pyridin-3-yl)-phenylamine (as prepared in the previous step, 73 mg, 0.36 mmol) and NBS (65 mg, 0.36 mmol) according to the procedure in Example 16, step (b) (20 mg, 20%). Mass spectrum (ESI, m/z): Calcd. for Cl2H11BrN2O, 279.0 (M+H), found 279.2.

Sources & evidence

ORD record
ord-3a8bc87b76bd42abaddfc5b49715444b
Source dataset
uspto-grants-2010_09
Patent number
US07790724B2

Reaction notes

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