4-Cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylic acid → HCID 86609181, compound

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Reaction Steps

3-Piperidin-1-yl-pyridazin-4-ylamine (as prepared in above step) was coupled with 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid, potassium salt (as prepared in Example 11, step (d)), as described in Example 42, step (c) to afford 5-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid (3-piperidin-1-yl-pyridazin-4-yl)-amide which was subjected to SEM deprotection as described in Example 47, step (d) to afford the title compound. 1H-NMR (DMSO-d6; 400 MHz): δ 9.79 (br s, 1H), 9.03 (d, 1H, J=4 Hz), 8.50 (s, 1H), 8.43 (d, 1H, J=4 Hz), 3.21 (m, 4H), 1.71-1.86 (m, 6H); Mass spectrum (ESI, m/z): Calcd. for C14H15N7O, 298.1 (M+H), found 298.1.

Provenance & Evidence