HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 4-Piperidinemethanol | HCID 420771 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate | HCID 736490 | 76% |
Reaction Steps
A mixture of piperidin-4-yl-methanol (0.57 g, 5 mmoles), benzyl chloroformate (0.75 ml, 5.5 mmoles), and sodium bicarbonate (0.46 g, 5.5 mmoles) in CH2Cl2 was stirred at room temperature for 2 hours, diluted with H2O and extracted with EtOAc. The extracts were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated under vacuum to afford the title compound (0.95 g, 3.8 mmoles).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790751B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-08f50b5298184d6ba84068687409fed3 |
| Source note | uspto-grants-2010_09 |