1-Benzyl-3-[3-(1-Naphthylsulfonylmethyl)-4-nitrophenoxy]-piperidine → 4-(1-Benzylpiperidin-3-yloxy)-2-(1-naphthylsulfonylmethyl)phenylamine

Participants

Reaction Steps

A mixture of 1-benzyl-3-[3-(1-naphthylsulfonylmethyl)-4-nitro-phenoxy]-piperidine (1.2 g, 2.3 mmoles) and 10% Pd/C in THF and methanol was hydrogenated in a Parr hydrogenation bottle at 52 lb/in2 overnight. The reaction mixture was filtered through Celite, and the filtrate was concentrated under vacuum to afford the title compound as an off-white solid (1.0 g, 2.03 mmoles).

Provenance & Evidence