Iodine → HCID 178526495, compound

Participants

Reaction Steps

A solution of 5-nitroindazole (8.50 g, 52.13 mmol) in DMF was treated with iodine (26.46 g, 104.27 mmol) and potassium hydroxide pellets (11.70 g, 208.54 mmol) at room temperature, stirred for 4 days, poured into NaHSO3 solution (11.06 g in 200 mL water) and filtered. The filtercake was washed with water and dried in vacuo to provide the title compound as a yellow solid, 14.74 g (98% yield), characterized by NMR and mass spectral analyses.

Provenance & Evidence