Acetic Acid → HCID 178452070, compound

Participants

Reaction Steps

A mixture of [3-(1-naphthylsulfonyl)-1H-indazol-5-yl]amine (400 mg, 1.24 mmol), 1-Boc-4-piperidone (493 mg, 2.47 mmol), sodium triacetoxyborohydride (524 mg, 2.47 mmol), and acetic acid (149 mg, 2.47 mmol) in 1,2-dichloroethane was stirred at room temperature overnight, diluted with CH2Cl2, washed with water, dried over Na2SO4 and concentrated in vacuo. The resultant residue was purified by column chromatography with 1% MeOH in CH2Cl2 as eluent to provide the title compound, 390 mg (62% yield), characterized by HNMR and mass spectral analyses.

Provenance & Evidence