Sodium Carbonate → HCID 67319132, compound

Participants

Reaction Steps

A similar procedure was followed as set out above for trans-N-{-2-[4-(6-methyl-3-pyridinyl)phenyl]cyclopropyl}-2-propanesulfonamide racemic (Example 2) using 3-bromo-5-fluoropyridine (66.5 mg, 0.378 mmol), trans-N-{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-2-propanesulfonamide (Intermediate 8) (69 mg, 0.189 mmol) in dry 1,4-dioxane (1.0 ml), polymer supported Tetrakis palladium catalyst (Pol-Pd(PPh3)4) (51 mg, 0.00567 mmol) and Na2CO3 2M (0.236 ml, 0.472 mmol) to give a crude product which was purified by reverse phase HPLC to give the title compound. The HPLC conditions were as given in “Preparative Chromatography” above.

Provenance & Evidence