反应详情

温度

80 °C

To 0.77 mmol 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid methyl ester in 2.5 ml ethanol was added 1.53 mmol 2 N aq NaOH solution, and the reaction mixture was stirred at 80° C. for 30 minutes. After such time the solvent was removed in vacuo, the residue was taken in water and acidified by addition of 2 N HCl. After filtration, the title compound was obtained as a white solid (92% yield). MS (m/e): 311.0 ([M−H]−, 100%)

1. customAfter such time the solvent was removed in vacuo
2. additionacidified by addition of 2 N HCl
3. filtrationAfter filtration