4-(4-methoxyphenoxy)piperidine → HCID 58673073, compound

HRID 1711732Notes

Reaction equation

HRID 1711732 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:32]=[CH:31][C:23]([O:24][CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:22][CH:21]=1>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:28]1[CH2:27][CH2:26][CH:25]([O:24][C:23]2[CH:31]=[CH:32][C:20]([O:19][CH3:18])=[CH:21][CH:22]=2)[CH2:30][CH2:29]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 34092334-(4-methoxyphenoxy)piperidineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 58673073HCID 58673073, compoundYield 73%

Procedure

Prepared in analogy to Example 1 from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 4-(4-methoxy-phenoxy)-piperidine. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 73%). MS (m/e): 448.2 (M+H+, 100%).

Workup

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

Sources & evidence

ORD record
ord-1236d25cd38b477aa055859f2b8171b4
Source dataset
uspto-grants-2010_09
Patent number
US07790763B2

Reaction notes

Loading…