1-(3-Fluoro-4-hydroxyphenyl)ethan-1-one → HCID 11619894, compound

HRID 1711737Notes

Reaction equation

HRID 1711737 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[C:14]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=2[O:20][CH:21]([CH3:23])[CH3:22])=[O:9])[CH2:4][CH2:3]1.[CH3:24][C:25]([C:27]1[CH:32]=[CH:31][C:30](O)=[C:29]([F:34])[CH:28]=1)=[O:26]>>[F:34][C:29]1[CH:28]=[C:27]([C:25](=[O:26])[CH3:24])[CH:32]=[CH:31][C:30]=1[O:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[C:10]2[CH:15]=[C:14]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=2[O:20][CH:21]([CH3:23])[CH3:22])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 27373251-(3-Fluoro-4-hydroxyphenyl)ethan-1-oneHCID 58673083(4-Hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Product 1

HCID 11619894HCID 11619894, compoundYield 21%

Procedure

Prepared in analogy to Example 4 from (4-hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 3(a)) and 3-fluoro-4-hydroxyacetophenone. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 21%). MS (m/e): 478.4 (M+H+, 100%).

Workup

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

Sources & evidence

ORD record
ord-1b829fd984494188a1451b48e9c6e6fb
Source dataset
uspto-grants-2010_09
Patent number
US07790763B2

Reaction notes

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