HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylparaben → 4-[1-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperidin-4-yloxy]-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | (4-Hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 58673083 | — |
| Product | 4-[1-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperidin-4-yloxy]-benzoic acid ethyl ester | HCID 58673065 | 28% |
Reaction Steps
Prepared in analogy to Example 4 from (4-hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 3(a)) and ethyl 4-hydroxybenzoate. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 28%). MS (m/e): 490.5 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790763B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-988608baf7b84b1c9011ef8a872ef156 |
| Source note | uspto-grants-2010_09 |