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HRID1711748

反应详情

EQUATION

反应方程式

HRID 1711748 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)c1ccc(O)c(F)c1
HCID2737325

3'-Fluoro-4'-hydroxyacetophenone

C8H7FO2

结构：CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCC(OS(C)(=O)=O)C1
HCID58673069

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)c1ccc(OC2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C)C2)c(F)c1
HCID58673061

未命名化合物

收率 62%

PROCEDURE

实验过程

Prepared in analogy to Example 3(c) from rac-methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester (Example 14(a)) and 3-fluoro-4-hydroxyacetophenone. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 62%). MS (m/e): 464.0 (M+H+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)