3-(Trifluoromethyl)phenol → Rac-(2-isopropoxy-5-methanesulfonyl-phenyl)-[3-(3-trifluoromethyl-phenoxy)-pyrrolidin-1-yl]-methanone

Participants

Reaction Steps

Prepared in analogy to Example 3(c) from rac-methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester (Example 14(a)) and 3-hydroxybenzotrifluoride. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 45%). MS (m/e): 472.4 (M+H+, 100%).

Provenance & Evidence