3,4-Dichlorophenol → Rac-[3-(3,4-dichloro-phenoxy)-pyrrolidin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Participants

Reaction Steps

Prepared in analogy to Example 3(c) from rac-methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester (Example 14(a)) and 3,4-dichlorophenol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 32%). MS (m/e): 476.3 ({37Cl}M+H+, 10%), 474.3 ({37C,35Cl}M+H+, 80%), 472.2 ({35Cl}M+H+, 100%)

Provenance & Evidence