HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthol → Rac-(2-isopropoxy-5-methanesulfonyl-phenyl)-[3-(naphthalen-2-yloxy)-pyrrolidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthol | HCID 8663 | — |
| Reactant | Rac-Methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester | HCID 58673069 | — |
| Product | Rac-(2-isopropoxy-5-methanesulfonyl-phenyl)-[3-(naphthalen-2-yloxy)-pyrrolidin-1-yl]-methanone | HCID 11539733 | 40% |
Reaction Steps
Prepared in analogy to Example 3(c) from rac-methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester (Example 14(a)) and 2-naphthol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous yellow solid (yield 40%). MS (m/e): 454.5 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790763B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-ef834a05377f4ef292f682181d8dcb6c |
| Source note | uspto-grants-2010_09 |