HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isopropoxy-5-methylsulfonylbenzoic acid → (3-Hydroxy-azetidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Reactant | Azetin-3-ol | HCID 68505089 | — |
| Product | (3-Hydroxy-azetidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 58673079 | 62% |
Reaction Steps
Prepared in analogy to Example 1 from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and azetin-3-ol. The crude material was purified by flash chromatography (methanol/dichloromethane) to yield the title compound as a pink solid (yield 62%). MS (m/e): 314.0 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790763B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-4772e60520514291ba8379d37d7c759d |
| Source note | uspto-grants-2010_09 |