HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[3-(4-trifluoromethyl-phenoxy)-azetidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzene, 1-fluoro-4-(trifluoromethyl)- | HCID 67873 | — |
| Reactant | (3-Hydroxy-azetidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 58673079 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (2-Isopropoxy-5-methanesulfonyl-phenyl)-[3-(4-trifluoromethyl-phenoxy)-azetidin-1-yl]-methanone | HCID 11510854 | — |
Reaction Steps
A mixture of 0.32 mmol (3-hydroxy-azetidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone, 0.32 mmol 4-fluoro-benzotrifluoride and 0.96 mmol cesium carbonate in 10 ml acetonitrile was refluxed overnight. The reaction mixture was concentrated to yield the crude compound, purified by chromatography (methanol/dichloromethane). MS (m/e): 458.4 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790763B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-b88390a285d54d3789afd7dfc92aa49e |
| Source note | uspto-grants-2010_09 |