1-Benzhydryl-3-[3-(trifluoromethyl)phenoxy]azetidine → 3-[3-(Trifluoromethyl)phenoxy]azetidine

Participants

Reaction Steps

44 mg of 10% palladium on charcoal was added to a solution of 0.23 mmol 1-benzhydryl-3-(3-trifluoromethyl-phenoxy)-azetidine in 5 ml acetic acid. The reaction mixture was hydrogenated for 3 hours at room temperature and normal pressure. Filtration and concentration yielded the crude product which was used in the next step without further purification. MS (m/e): 218.2 (M+H+, 100%).

Provenance & Evidence