Benzene, 1-fluoro-4-(trifluoromethyl)- → [5-Methanesulfonyl-2-((s)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[3-(4-trifluoromethyl-phenoxy)-azetidin-1-yl]-methanone

Participants

Reaction Steps

Prepared in analogy to Example 21(b) from (3-hydroxy-azetidin-1-yl)-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone and 4-fluorobenzotrifluoride. The crude material was purified by flash chromatography (methanol/dichloromethane) to yield the title compound as a white crystalline solid (yield 5%). MS (m/e): 512.5 (M+H+, 100%).

Provenance & Evidence