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HRID1711763

反应详情

EQUATION

反应方程式

HRID 1711763 的结构方程式

REACTANTS

反应物

2
结构：Fc1ccc(C(F)(F)F)cc1
HCID67873

4-Fluorobenzotrifluoride

C7H4F4

结构：C[C@@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CC(O)C1)C(F)(F)F
HCID58673082

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CC(Oc2ccc(C(F)(F)F)cc2)C1)C(F)(F)F
HCID11562544

未命名化合物

收率 9%

PROCEDURE

实验过程

Prepared in analogy to Example 21(b) from (3-hydroxy-azetidin-1-yl)-[5-methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone and 4-fluorobenzotrifluoride. The crude material was purified by flash chromatography (methanol/dichloromethane) to yield the title compound as a white crystalline solid (yield 9%). MS (m/e): 512.3 (M+H+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by flash chromatography (methanol/dichloromethane)