3-[4-(Trifluoromethyl)phenoxy]pyrrolidine → HCID 11684721, compound

HRID 1711766Notes

Reaction equation

HRID 1711766 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].[F:20][C:21]([F:35])([F:34])[C:22]1[CH:33]=[CH:32][C:25]([O:26][CH:27]2[CH2:31][CH2:30][NH:29][CH2:28]2)=[CH:24][CH:23]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:9]([C:10]([N:29]2[CH2:30][CH2:31][CH:27]([O:26][C:25]3[CH:24]=[CH:23][C:22]([C:21]([F:20])([F:35])[F:34])=[CH:33][CH:32]=3)[CH2:28]2)=[O:12])[CH:13]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 187231273-[4-(Trifluoromethyl)phenoxy]pyrrolidineHCID 211003195-(Methanesulfonyl)-2-(morpholin-4-yl)benzoic acid

Product 1

HCID 11684721HCID 11684721, compoundYield 20%

Procedure

Prepared in analogy to Example 1 from 5-methanesulfonyl-2-morpholin-4-yl-benzoic acid (Example A4) and 3-(4-trifluoromethyl-phenoxy)-pyrrolidine. The crude material was purified by chromatography (methanol/dichloromethane) to yield the title compound as a white solid (yield 20%). MS (m/e): 499.4 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (methanol/dichloromethane)

Sources & evidence

ORD record
ord-6341dd8bfda34028afbdb23d7d14f77c
Source dataset
uspto-grants-2010_09
Patent number
US07790763B2

Reaction notes

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