3-[4-(Trifluoromethyl)phenoxy]pyrrolidine → HCID 11670727, compound

HRID 1711767Notes

Reaction equation

HRID 1711767 reaction equation
[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16](=[O:20])(=[O:19])[NH:17][CH3:18])=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:21][C:22]([F:36])([F:35])[C:23]1[CH:34]=[CH:33][C:26]([O:27][CH:28]2[CH2:32][CH2:31][NH:30][CH2:29]2)=[CH:25][CH:24]=1>>[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([NH:17][CH3:18])(=[O:20])=[O:19])=[CH:12][C:8]=2[C:9]([N:30]2[CH2:31][CH2:32][CH:28]([O:27][C:26]3[CH:25]=[CH:24][C:23]([C:22]([F:21])([F:36])[F:35])=[CH:34][CH:33]=3)[CH2:29]2)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 187231273-[4-(Trifluoromethyl)phenoxy]pyrrolidineHCID 21100227HCID 21100227, compound

Product 1

HCID 11670727HCID 11670727, compoundYield 11%

Procedure

Prepared in analogy to Example 1 from 2-cyclopentyloxy-5-methylsulfamoyl-benzoic acid (Example A5) and 3-(4-trifluoromethyl-phenoxy)-pyrrolidine (Example 25(b)). The crude material was purified by chromatography (methanol/dichloromethane) to yield the title compound as an off-white solid (yield 11%). MS (m/e): 513.5 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (methanol/dichloromethane)

Sources & evidence

ORD record
ord-940401da2ab6407bb3f37993c58ff378
Source dataset
uspto-grants-2010_09
Patent number
US07790763B2

Reaction notes

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