3-[4-(Trifluoromethyl)phenoxy]pyrrolidine → HCID 58673081, compound

HRID 1711768Notes

Reaction equation

HRID 1711768 reaction equation
[CH:1]([S:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[F:18][C:19]([F:33])([F:32])[C:20]1[CH:31]=[CH:30][C:23]([O:24][CH:25]2[CH2:29][CH2:28][NH:27][CH2:26]2)=[CH:22][CH:21]=1>>[CH:1]([S:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:27]1[CH2:28][CH2:29][CH:25]([O:24][C:23]2[CH:22]=[CH:21][C:20]([C:19]([F:18])([F:33])[F:32])=[CH:31][CH:30]=2)[CH2:26]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 187231273-[4-(Trifluoromethyl)phenoxy]pyrrolidineHCID 211002522-Isopropylsulfanyl-5-methanesulfonyl-benzoic acid

Product 1

HCID 58673081HCID 58673081, compoundYield 42%

Procedure

Prepared in analogy to Example 1 from 2-isopropylsulfanyl-5-methanesulfonyl-benzoic acid (Example A6) and 3-(4-trifluoromethyl-phenoxy)-pyrrolidine (Example 25(b)). The crude material was purified by chromatography (methanol/dichloromethane) to yield the title compound as a light brown solid (yield 42%). MS (m/e): 488.1 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (methanol/dichloromethane)

Sources & evidence

ORD record
ord-4663bb4dbe74417b89f40f4c1244d020
Source dataset
uspto-grants-2010_09
Patent number
US07790763B2

Reaction notes

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